Job Description

 

Senior Scientist (Display Technologies)

Tokyo lab

 

OriCiro Genomics is seeking a highly motivated Senior Scientist to setup phage and yeast display capabilities. The candidate will play a key role in establishing the aforementioned technologies as well as implementing any appropriate downstream analyses and optimizations of hits/probes coming out of the panning efforts. They will report to and work closely with the Chief Technology Officer. The candidate will also manage other scientists where needed to accelerate development.

 

Description of Duties         

  • Compare and determine appropriate phage and yeast display technologies for panning a wide variety of protein scaffolds (antibody, Fab, scFv, etc.).

  • Library design and construction for the discovery of a wide variety of protein scaffolds (antibody, Fab, scFv, etc.).

  • Analyze libraries using NGS and measure activity of isolated hits using various binding assays (ELISA, TR-FRET, SPR, flow cytometry, etc.).

  • Apply bioinformatics and structural analysis tools to aid in hit optimization.

  • Organize and execute multiple projects in a fast-pace and collaborative environment

 

Minimum qualifications

  • PhD in biological sciences or a relevant field and biologics drug discovery in biotech/pharmaceutical industry, or M.S. with 4+ years of industry experience.

  • Direct hands-on experience in library construction, screening and evaluating various display technologies including phage display (M13, fd, T4, T7, λ, etc.) and yeast display.

  • Proficiency in a wide variety of binding assays (ELISA, TR-FRET, SPR, flow cytometry, etc.) and the ability to set up custom binding assays where needed.

  • Bioinformatics capabilities to analyze NGS data from panning efforts.

  • Ability to work in an independently, highly organized manner and propose creative yet critical troubleshooting solutions.

  • The ability to rapidly understand and learn new technologies that aid in biological analysis and integrate new technologies into existing projects.

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